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Ceftaroline fosamil (INN) , brand name Teflaro in the US and Zinforo in Europe, is an advanced-generation cephalosporin antibiotic. It is active against methicillin-resistant ''Staphylococcus aureus'' (MRSA) and Gram-positive bacteria. It retains the activity of later-generation cephalosporins having broad-spectrum activity against Gram-negative bacteria. It is currently being investigated for community-acquired pneumonia〔 and complicated skin and skin structure infection.〔〔〔 Ceftaroline is being developed by Forest Laboratories, under a license from Takeda. '' Ceftaroline has received approval from the U.S. Food and Drug Administration for the treatment of community-acquired bacterial pneumonia and acute bacterial skin infections on October 29, 2010. ''In vitro'' studies show it has a similar spectrum to ceftobiprole, the only other fifth-generation cephalosporin to date, although no head-to-head clinical trials have been conducted. Ceftaroline and ceftobiprole are on an unnamed subclass of cephalosporins by the Clinical and Laboratory Standards Institute (CLSI). == Clinical use == (詳細はphase III clinical trials for complicated skin and skin structure infections with reported non-inferior efficacy against MRSA compared to vancomycin and aztreonam. In 2009, ceftaroline had completed phase-III clinical trials for community-acquired pneumonia comparing it against ceftriaxone with non-inferior results and similar adverse reaction profile. However, only results for phase-II clinical trials in treatment of complicated skin and skin structure infections have been published. Sept 2009 : Phase III trials results reported. On September 8, 2010, the FDA Advisory Committee recommended approval for the treatment of community acquired bacterial pneumonia and complicated skin and skin structure infections. In Oct 2010, the FDA approval was gained for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections, including MRSA. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Ceftaroline fosamil」の詳細全文を読む スポンサード リンク
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